P129335-1gPirfenidone
面议
- 阿拉丁
- 生产商
- P129335-1g
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C12H11NO
- 分子量185.22
- Beilstein号 21(5)7,197
- EC号
- MDL号 MFCD00866047
- PubChem编号
属性
溶解性 | Soluble in water (>10 mg/ml at 60 °C), chloroform, DMSO (>20 mg/ml), ethanol, and DMF. |
描述
应用 | An antifibrotic and antioxidant small molecule |
产品介绍 | Pirfenidone is a small molecule antifibrotic agent. In pulmonary fibrosis studies, Pirfenidone is shown to block collagen production and mitigate the presentation of bleomycin- and cyclophosphamide-induced fibrosis. This intervention appears in part on the transcriptional level, with Pirfenidone exposure correlating to a significant decrease in levels of procollagen I and III gene-assoicated messenger RNA. The antioxidant radical-scavenging activity additionally demonstrated by Pirfenidone suggests a role in protecting against lipid peroxidation, and may attribute to the antifibrotic property of the compound. |
备注 | Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Phase 3. |
生化机理 | Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials. |
别名 | 5-甲基-1-苯基-2-(1H)-吡啶酮;吡非尼酮;5-Methyl-1-phenyl-2-pyridone; 5-Methyl-1-phenyl-2-(1H)-pyridone |
Reaxys-RN | 1526549 |
信号词 | Warning |
危害声明 | H302 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
RTECS | UV1148200 |
WGK德国 | 3 |
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