D119514-250mg2',3'-二脱氧胞苷
面议
- 阿拉丁
- 生产商
- D119514-250mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C9H13N3O3
- 分子量211.22
- Beilstein号 654956
- EC号
- MDL号 MFCD00012188
- PubChem编号 24278377
属性
熔点 | 209°C |
旋光率 | +75.0 to +80.0°(C=1, H2O) |
溶解性 | Soluble in water (76.4 mg/ml at 25°C), DMSO (42 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C). |
存贮条件 | 储存温度-20°C |
描述
应用 | 2',3'-二脱氧胞苷 ;2,3-二脱氧胞嘧啶核苷 2',3'-二脱氧胞甙 双脱氧胞嘧啶核苷 2',3-双脱氧胞嘧啶核苷 扎西胞苷扎西他滨 ;2′,3′-Dideoxycytidine ;7481-89-2; C9H13N3O3 |
生化机理 |
Zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NARTI). Zalcitabine is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Zalcitabine is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite works as a substrate for HIV reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. Since Zalcitabine is a reverse transcriptase inhibitor it possess activity only against retroviruses. |
别名 | 2,3-二脱氧胞嘧啶核苷 ,2',3'-二脱氧胞甙 ,双脱氧胞嘧啶核苷 ,2',3-双脱氧胞嘧啶核苷 ,扎西胞苷,扎西他滨 ;ddC,1-(2,3-Dideoxy-β-D-ribofuranosyl)cytosine,Zalcitabine |
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