耗材描述
- 分子式 C15H10O6
- 分子量286.24
- Beilstein号 292084
- EC号 207-741-0
- MDL号 MFCD00017309
- PubChem编号 24896520
属性
熔点 | 330°C |
溶解性 | Soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO (7 mg/ml), 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (`~1 mg/ml), water (1 mg/ml) at 25 °C, and methanol. |
存贮条件 | 贮存温度2-8℃ |
密度 | 1.6540 |
描述
应用 | An inhibitor of glutathione S-transferase and 15-LO. |
产品介绍 | Luteolin is an antioxidant flavonoid and a free radical scavenger. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T?CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Luteolin is an inhibitor of Cot, PDE1-5, c-Src, HDAC, Maltase-glucoamylase, Topo I, PKC ε, Fatty Acid Synthase, PPAR γ and MMP. |
别名 | 木犀草素;3',4',5,7-四羟基黄酮,黄色黄素,黄示灵,藤黄菌素3',4',5,7-Tetrahydroxyflavone |
Merck Index | 5614 |
标识符号 |
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信号词 | Warning |
危害声明 | H315,H319,H335 |
警示性声明 | P261,P305+P351+P338 |
个人防护设备 | dust mask type N95 (US),Eyeshields,Gloves |
RTECS | LK9275210 |
WGK德国 | 3 |
风险声明 (欧洲) | R36/37/38; |
安全声明(欧洲) | S26;S36; |
危害码(欧洲) | Xi |
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