ALS2CR2 Antibody(C-term)
Cat.#: T2031
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q9C0K7
Mol Weight: 47kDa
Size: 100ug

Description
ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.

Recommended Applications
WB, ELISA

Applications and Recommended Dilution Factors
WB: 1:100~500
ELISA: 1:1,000

Species Reactivity
Human

Products Data

Western blot analysis of ALS2CR2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). ALS2CR2 (arrow) was detected using the purified Pab.

Specificity
This ALS2CR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389~418 amino acids from the C-terminal region of human ALS2CR2.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
STRADB antibody, ALS2CR2 antibody, CALS-21 antibody, ILPIP antibody, ILPIPA antibody, MGC102916 antibody, PAPK antibody, STE20-related kinase adapter protein beta antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein antibody, CALS-21 antibody, ILP-interacting protein antibody, Pseudokinase ALS2CR2 antibody

Description References
Nishigaki, K., et al., J. Biol. Chem. 278(15):13520-13530 (2003).
Sanna, M.G., et al., J. Biol. Chem. 277(34):30454-30462 (2002).
Hadano, S., et al., Genomics 71(2):200-213 (2001).

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途