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药物分子
FK866 (APO866, Daporinad)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| F127321-5mg | 658084-64-1 | 询底价 |
| F127321-100mg | 658084-64-1 | 询底价 |
| F127321-25mg | 658084-64-1 | 询底价 |
产品介绍
属性
| 敏感性 | 易吸湿 |
| 溶解性 | Soluble in ethanol (78 mg/ml at 25 °C), DMF (40 mg/ml), DMSO (100 mg/ml), PBS (pH 7.2) (~0.5 mg/ml), and water (<1 mg/ml at 25 °C), DMSO 25mg/ml Ethanol dimethyl formamide |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A highly specific non-competitive inhibitor of NAMPT |
| 产品介绍 | FK866 (APO866, Daporinad)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase)，无细胞试验中IC50为0.09 nM。Phase 1/2。 |
| 备注 | APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. Phase 1/2. |
| 生化机理 | FK-866 has been shown to induce apoptosis by non-competitive, and specific inhibition of nicotamide phosphoribosyltransferase (NAMPT). NAMPT is a key regulatory enzyme that mediates NAD+ biosynthesis within cells. Mechanistic studies show that this compound contains an enzymatic active site of visfatin which is optimized for nicotinamide binding and inhibition. Visfatin also contains a similar structure to insulin and mimics its actions by binding to the insulin receptors. |
| 别名 | (2E)-N-[4-(1-苯甲酰基-4-哌啶基)丁基]-3-(3-吡啶基)-2-丙烯酰胺;Daporinad; APO866; FK-866; FK 866; APO 866; APO-866;(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide |
FK866 (APO866, Daporinad)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于FK866 (APO866, Daporinad)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途