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其他小分子
GW3965 HCl
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
AI问答
配套的仪器设备？
可以搭配的相关耗材试剂？
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| G129708-100mg | 405911-17-3 | 询底价 |
| G129708-10mg | 405911-17-3 | 询底价 |
| G129708-1mg | 405911-17-3 | 询底价 |
| G129708-50mg | 405911-17-3 | 询底价 |
| G129708-5mg | 405911-17-3 | 询底价 |
产品介绍
- 分子式 C33H31ClF3NO3.HCl
- 分子量618.51
- Beilstein号
- EC号
- MDL号 MFCD08276920
- PubChem编号 24724494
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | GW3965 hydrochloride |
| 备注 | GW3965 is a potent, selective LXRagonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
| 生化机理 | GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively. |
| 别名 | ;N/A; GW3965 hydrochloride; 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride |
GW3965 HCl信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于GW3965 HCl报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途