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激酶
AG-490 (Tyrphostin B42)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A126525-1g | 133550-30-8 | 询价 |
| A126525-20mg | 133550-30-8 | 询价 |
| A126525-250mg | 133550-30-8 | 询价 |
| A126525-50mg | 133550-30-8 | 询价 |
产品介绍
- 分子式 C17H14N2O3
- 分子量294.3
- Beilstein号
- EC号 MFCD00236452
- MDL号
- PubChem编号
属性
| 熔点 | 215°C |
| 溶解性 | DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells |
| 产品介绍 | AG-490 (Tyrphostin AG 490)是EGFR抑制剂，IC50为100nM，比对ErbB2的抑制性高135倍，对Lck，Lyn，Btk，Syk和Src无活性。 |
| 备注 | AG-490 (Tyrphostin B42) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. |
| 生化机理 |
AG-490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo. |
| 别名 | 酪氨酸激酶抑制剂AG 490;(E)-N-苯甲基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺 ;AG 490;Tyrphostin AG 490;AG490; tyrphostin ag 490;ag 490; (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途