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AG-1024
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| A126115-100mg | 65678-07-1 | 询价 |
| A126115-25mg | 65678-07-1 | 询价 |
| A126115-5mg | 65678-07-1 | 询价 |
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | AG-1024 (Tyrphostin)能抑制IGF-1R自磷酸化，IC50为7 μM，而对IR的IC50则为57 μM。 |
| 备注 | AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins). |
| 生化机理 |
AG1024 (Tyrphostin AG 1024), one selective inhibitor of IGF-1R, was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function. Human breast cancer cell studies report AG1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG1024 decreases Ang II-mediated NAD(P)H oxidase activation. |
| 别名 | HY-10253; AG 1024; AGS 200;Tyrphostin AG 1024;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile |
AG-1024信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于AG-1024报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途