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酶·辅酶
Etoposide
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| E121713-100mg | 33419-42-0 | 询价 |
| E121713-1g | 33419-42-0 | 询价 |
| E121713-250mg | 33419-42-0 | 询价 |
| E121713-500mg | 33419-42-0 | 询价 |
| E121713-5g | 33419-42-0 | 询价 |
产品介绍
- 分子式 C29H32O13
- 分子量588.56
- Beilstein号
- EC号 251-509-1
- MDL号 MFCD00869325
- PubChem编号 24278178
属性
| 熔点 | 251°C |
| 旋光率 | -110.5° (C=0.6,CHCl3) |
| 溶解性 | Soluble in DMSO (30 mg/ml), dimethyl formamide, ethyl ether, chloroform:methanol (1:1), methanol (slightly), acetone (slightly), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C |
描述
| 应用 |
Inhibits DNA synthesis via topoisomerase II inhibition Etoposide has been used: · to prepare drug stock solution in dimethyl sulfoxide (DMSO) and also to profile and compare the sensitivity of DT40 mutant cells · to incubate cells for cell viability assay · to treat neuro-2A cells to induce programmed cell death |
| 产品介绍 | 依托泊苷是一种抗肿瘤剂，它与拓扑异构酶Ⅱ及DNA结合成复合物，以增强双链和单链DNA的裂解，并可逆地抑制再连接。在细胞周期S期和G2期阻断细胞周期，在正常和肿瘤细胞系中诱导细胞凋亡，抑制癌蛋白Mdm2的合成，在过渡表达Mdm2的肿瘤细胞系中诱发细胞凋亡。 |
| 生化机理 | Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2. |
| 别名 | 4'-去甲表鬼臼9 -（4,6-O-亚乙基-β-e-吡喃葡萄糖苷）VP-16-213;依托泊苷;4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside) |
Etoposide信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Etoposide报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途