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酶·辅酶
N-叔丁基-а-苯基硝酮
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
B100838-5g | 3376-24-7 | 询价 |
B100838-25g | 3376-24-7 | 询价 |
B100838-1g | 3376-24-7 | 询价 |
产品介绍
- 分子式 C11H15NO
- 分子量177.24
- Beilstein号 2044028
- EC号 222-168-6
- MDL号 MFCD00008799
- PubChem编号 24891981
属性
熔点 | 72-75°C |
敏感性 | 对空气敏感 |
溶解性 | 溶于DMSO (10 mg/ml), 氯仿 (50 mg/ml), 和水(20 mg/ml). |
存贮条件 | 储存温度 -20°C,充氩保存 |
密度 | 0.9900 |
描述
应用 | 一种Cox-2抑制剂。 |
产品介绍 | N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g). |
别名 | N-叔丁基苯硝酮;N-苯亚甲基叔丁胺-N-氧化物;叔丁基(亚苄基)胺 N-氧化物;PBN;N-Benzylidene-tert-butylamine N-oxide; PBN; Phenyl N-t-butylnitrone; Phenyl N-tert-butylnitrone; |
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途