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N-甲酰-L-甲硫氨酰-L-白氨酰-L苯丙氨酸
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
AI问答
配套的仪器设备？
可以搭配的相关耗材试剂？
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| F113682-10mg | 59880-97-6 | 询底价 |
| F113682-25mg | 59880-97-6 | 询底价 |
| F113682-5mg | 59880-97-6 | 询底价 |
产品介绍
- 分子式 C21H31N3O5S
- 分子量437.55
- Beilstein号 2315783
- EC号
- MDL号 MFCD00036780
- PubChem编号 24894846
属性
| 敏感性 | 对热敏感 |
| 存贮条件 | -20°C保存 |
描述
| 应用 |
N-Formyl-Met-Leu-Phe has been used for: · creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils · use in neutrophil chemotaix assayand · determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe. |
| 生化机理 | N-Formyl-Met-Leu-Phe induced chemotaxis in phosphoinositide 3-kinase γ (PI3K)γ-/- neutrophils, and promotes adhesion, polymerization of F-actin, Fcγ receptor-mediated phagocytosis and intracellular Ca2+ release. It acts as an inflammatory agent and activates polymorphonuclear leukocytes (PMNs) without the formation of 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). Its effects on neutrophils and the inhibition of adenylate cyclase are inhibited by pertussis toxin. Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion. Potent inducer of leucocyte chemotaxis and macrophage activator. Receptors that bind formylpeptides are found on phagocytic neutrophils and have recently been identified on cells of the intestinal mucosa. |
| 别名 | N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸,趋化肽,fMLP;Chemotactic peptide fMLF fMLP (misnomer but widely used) N-Formyl-L-methionyl-L-leucyl-L-phenylalanine |
N-甲酰-L-甲硫氨酰-L-白氨酰-L苯丙氨酸信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于N-甲酰-L-甲硫氨酰-L-白氨酰-L苯丙氨酸报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途