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Varenicline tartrate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| V120183-1g | 375815-87-5 | 询价 |
| V120183-250mg | 375815-87-5 | 询价 |
| V120183-25mg | 375815-87-5 | 询价 |
| V120183-50mg | 375815-87-5 | 询价 |
| V120183-5mg | 375815-87-5 | 询价 |
产品介绍
- 分子式 C13H13N3·C4H6O6
- 分子量361.35
- Beilstein号
- EC号
- MDL号 MFCD08460603
- PubChem编号
属性
| 溶解性 | DMSO: >5 mg/mL |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | An AChR α4β2 partial agonist.Varenicline tartrate has been used to investigate its effect on sensorimotor gating in rats under prepulse inhibition (PPI). It is suitable for use as a reference standard in capillary isotachophoresis (ITP) coupled on-line with capillary zone electrophoresis (CZE) for the quantification of varenicline metabolite in urine samples. It is also suitable for use for testing its effect on locomotor and nonlocomotor behavioral deficits in rats. |
| 生化机理 | arenicline Tartrate is an AChR α4β2 partial agonist with a Ki value of 0.06 nM.Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking. |
| 别名 | 酒石酸伐尼克兰;7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate Champix;CP 526555-18;Champix tartrate;Chantix tartrate |
Varenicline tartrate信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Varenicline tartrate报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途