The Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.

• Desired selectivity for pharmaceutical mono- and multi-valent counterion screening
• Retention of ionic and ionizable analytes without using ion-pairing reagents
• Compatibility with charged aerosol and mass spectrometry detection methods
• Easy to use
• Rugged packing

The Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 µm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.

NSH Chromatographic Features

Multiple retention mechanisms including HILIC, anion-exchange, and cation-exchange
Adjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solvent
Ideal selectivity for simultaneous separation of basic, neutral, and acidic analytes
Separation of hydrophilic ionic and ionizable analytes without ion-pairing reagents

Acclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications Specifications
Column chemistry	SAX, WCX and HILIC Mixed-Mode
Operating pressure limit	6000 psi
Operating pH range	2.0 – 8.0
Operating flow rate range	0.3 – 0.90 mL/min for 3.0-mm i.d. formats 0.15 – 0.45 mL/min for 2.1-mm i.d. formats
Organic compatibility	Compatible with most common HPLC organic solventsexcept for alcohols.
Aqueous compatibility	0-100% aqueous mobile phase
Storage solution	MeCN/10mM NH₄OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile)

Separation of 12 common pharmaceutical counterions (both anions and cations) in less than 15 minutes using the Trinity P2 column.

Separation of a hydrophilic drug and counterion under HILIC conditions.

Analytical Columns
Acclaim Trinity P2,3µm,Analytical column, 3.0 x 50mm	085433
Acclaim Trinity P2,3µm,Analytical column, 3.0 x 100mm	085434
Acclaim Trinity P2,3µm,Analytical column, 2.1 x 50mm	085431
Acclaim Trinity P2,3µm, Analytical column, 2.1 x 100mm	085432

Guard Columns
Acclaim Trinity P2,3µm,Guard column, 3.0 x 10mm, 2/pk; requires holder 069580	085436
Acclaim Trinity P2,3µm,Guard column, 2.1 x 10mm, 2/pk; requires holder 069580	085435
Acclaim SST Guard Cartridge Holder V-2	069580
Acclaim Guard Kit (Holder and coupler) V-2	069707
Guard to Analytical Column Coupler V-2	074188

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