DL-Borneol | MedChemExpress (MCE)
品牌 | 厂商性质 | 产地 | 货期 | 价格 |
---|---|---|---|---|
MedChemExpress (MCE) | 生产商 | 美国 | 现货 | 1580 |
性能特点
DL-Borneol是D-Borneol和L-Borneol的外消旋混合物。DL-Borneol在中国广泛用于心血管和脑血管疾病的治疗。
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 507-70-0 | ¥480.00 | 询底价 |
500 mg | 507-70-0 | ¥1,580.00 | 询底价 |
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CAS No. : 507-70-0
MCE 国际站:DL-Borneol
产品活性:DL-Borneol是D-Borneol和L-Borneol的外消旋混合物。DL-Borneol在中国广泛用于心血管和脑血管疾病的治疗。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点:GABA Receptor | Endogenous Metabolite
结构分类:其他类
In Vitro: DL-Borneol increases intracellular accumulation of Rho123, and enhances P-gp substrates across the BBB in vitro, and also depresses mdr1a mRNA and P-gp expression. Furthermore, DL-Borneol could activate NF-κB and inhibition of NF-κB with MG132 and SN50 obscures the P-gp decreases induced by DL-Borneol. 10 μg/mL and 20 μg/mL DL-Borneol significantly increase phosphorylation of IκB expression at 30 min after treatment transiently. DL-Borneol treatment decreases P-gp expression in BMECs.
In Vivo: DL-Borneol significantly suppresses the process of epileptogenesis in PTZ-kindled mice. The biochemical alterations induced by PTZ kindling are ameliorated in DL-Borneol-treated animals which is indicated by decreased LPO and increased SOD, GSH, CAT levels. The distinct neuronal damage observed in the kindled group is counteracted by DL-Borneol. Furthermore, it decreases the levels of GFAP which is manifested by reduced immunostaining. The pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of DL-Borneol and that there are some components in Xingnaojing inhibiting the absorption of DL-Borneol.
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Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-N1368
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途