Histatin 5 | MedChemExpress (MCE)
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MedChemExpress (MCE) | 生产商 | 美国 | 订货 |
性能特点
Histatin 5 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性,IC50 分别为 0.57 和 0.25 μM。
CAS号 | 操作 |
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115966-68-2 | 询底价 |
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CAS No. : 115966-68-2
MCE 国际站:Histatin 5
产品活性:Histatin 5 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性,IC50 分别为 0.57 和 0.25 μM。
研究领域:Metabolic Enzyme/Protease
作用靶点:MMP
In Vitro: Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC50, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM. Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 μM inhibits state 2 respiration.
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途