Palbociclib isethionate
面议
- 阿拉丁
- 生产商
- 国产
- 上海
- 现货
- 全国
- 3
- 0
分子式 C24H29N7O2·C2H6O4S 分子量573.66 Beilstein号 EC号 MDL号 MFCD22666589 PubChem编号 属性 溶解性 DMSO <1 mg/mL (<1 mM); Water 50
| 货号 | CAS号 | 操作 |
|---|---|---|
| E129978-100mg | 827022-33-3 | 询底价 |
| E129978-25mg | 827022-33-3 | 询底价 |
| E129978-500mg | 827022-33-3 | 询底价 |
耗材描述
- 分子式 C24H29N7O2·C2H6O4S
- 分子量573.66
- Beilstein号
- EC号
- MDL号 MFCD22666589
- PubChem编号
属性
| 溶解性 | DMSO <1 mg/mL (<1 mM); Water 50 mg/mL heating (87.15 mM); Ethanol <1 mg/mL (<1 mM) |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 |
PD 0332991 isethionate has been used: · to incubate MCF10A cells to verify cyclin D1 inhibition of autophagy involved cyclin-dependent kinase activity · as a cyclin dependent kinase 4 (CDK4) inhibitor to study its anticonvulsive property in Drosophila · to mimic the inhibitory effect of 5α-dihydrotestosterone (DHT) on HPr-1AR cell cycle progression and growth |
| 产品介绍 | Palbociclib (PD0332991) Isethionate是一种高度选择性的CDK4/6抑制剂，IC50为11 nM/16 nM，对CDK1/2/5， EGFR， FGFR， PDGFR， InsR等没有抑制活性。Phase 3。 |
| 合法信息 | Sold for only research purposes |
| 备注 | Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 2/3. |
| 生化机理 | PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC50 = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells. PD 0332991 might act as a chemsensitizer. It is useful in the treatment of breast cancer along with antioestrogens. PD 0332991 is also known to possess antitumor action. |
| 别名 | 6-乙酰基-8-环戊基-5-甲基-2 - [[5-（1-哌嗪基）-2-吡啶基]氨基]吡啶并[2,3-d]嘧啶-7（8H） - 酮2-羟基 - 乙磺酸（1：1）, 帕博西尼羟乙基磺酸盐;PD0332991 isethionate; PD-0332991 isethionate; PD 0332991 isethionate;6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1) |
猜你喜欢
感兴趣产品