| 应用 |
A cell-permeable, nonpeptidic Bcl-2 inhibitor |
| 产品介绍 |
HA14-1是非肽类Bcl-2表面口袋配体，IC50为9 μM。 |
| 备注 |
HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM. |
| 生化机理 |
HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS. |
| 别名 |
HA-14-1; HA 14-1; 2-氨基-6-溴-alpha-氰基-3-(乙氧基羰基)-(alphaR,4R)-rel-4H-1-苯并吡喃-4-乙酸乙酯;;HA-14-1; HA 14-1;2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphar,4r)-rel-4h-1-benzopyran-4-acetic acid ethyl ester；Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
