| 产品介绍 |
Sofosbuvir (PSI-7977, GS-7977) 是一种 HCV的NS5B polymerase抑制剂，用于治疗慢性丙型肝炎病毒(HCV)的感染。 |
| 生化机理 |
PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection. PSI-7851 is a mixture of two similar molecules, PSI-7976 and PSI-7977, which exist in PSI-7851 as isomers of each other. Once inside a liver cell, both molecules are rapidly converted to the same active triphosphate. Given the ability to more easily manufacture PSI-7977, and potentially advantageous in vitro characteristics, PSI-7977 was selected for further clinical development. Antiviral agents |
| 别名 |
索非布韦;索氟布韦;PSI-7977, GS-7977;N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;PSI 7977;PSI-7977, GS-7977;N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester |
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