耗材描述

• 分子式 C₂₇H₃₃N₃O₆S
• 分子量527.63
• Beilstein号
• EC号
• MDL号 MFCD00631870
• PubChem编号

属性

溶解性	Soluble in DMSO (105 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (6 mg/ml at 25 °C).

描述

应用	An ATP-dependent K+ (KATP) channel blocker.
产品介绍	Gliquidone是一种ATP敏感的K+通道拮抗剂，IC50为27.2 nM
备注	Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
生化机理	Gliquidone is an ATP-dependent K+ (KATP) channel blocker. Gliquidone is an anti-diabetic drug in the sulfonylurea class. Gliquidone is used in the treatment of diabetes mellitus type 2. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
别名	糖肾平;格列喹酮;3-环己基-1-[4-[2-(3,4-二氢-7-甲氧基-4,4-二甲基-1,3-双氧基-2-(1H)-异喹啉基)-乙基]苯基]磺酰基-脲;3-Cyclohexyl-1-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-isoquinolin-2-yl)ethyl]phenyl]sulfonyl-urea

Reaxys-RN	1559726
RTECS	DB1584250

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