应用 |
A highly selective H+,K+-ATPase inhibitor that is more potent in acidic conditions. |
产品介绍 |
PF-3716556是一种有效的,选择性的P-CAB钾离子竞争性酸抑制剂,在离子渗透和离子密集检测中,抑制猪H+,K+-ATPase活性,抑制胃酸分泌,对Na+,K+-ATPas没有作用活性,用于治疗胃食管返流疾病。 |
合法信息 |
Sold for only research purposes |
备注 |
PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, i |
生化机理 |
PF 3716556 is a highly selective H+,K+-ATPase inhibitor which has been found to be more potent in acidic conditions. |
别名 |
8-[[(4R)-3,4-二氢-5-甲基-2H-1-苯并吡喃-4-基]氨基]-N-(2-羟基乙基)-N,2-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺;PF-03716556;PF03716556;8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide |