TRAM-34
面议
- 阿拉丁
- 生产商
- 国产
- 上海
- 现货
- 全国
- 4
- 0
分子式 C22H17ClN2 分子量344.84 Beilstein号 EC号 MFCD09842562 MDL号 MFCD09842562 PubChem编号 属性 溶解性 Soluble in DMSO (10 mg/ml at 40°
| 货号 | CAS号 | 操作 |
|---|---|---|
| T129575-100mg | 289905-88-0 | 询底价 |
| T129575-25mg | 289905-88-0 | 询底价 |
| T129575-50mg | 289905-88-0 | 询底价 |
| T129575-5mg | 289905-88-0 | 询底价 |
耗材描述
- 分子式 C22H17ClN2
- 分子量344.84
- Beilstein号
- EC号 MFCD09842562
- MDL号 MFCD09842562
- PubChem编号
属性
| 溶解性 | Soluble in DMSO (10 mg/ml at 40°C), ethanol (6 mg/ml at 40°C), and DMF (>25 mg/ml), dichloromethane, ethyl acetate, and methanol. Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| 产品介绍 | TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase. |
| 备注 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| 别名 | 1-[(2-氯苯基)二苯甲基]-1H-吡唑;1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole |
猜你喜欢
感兴趣产品