CPI-613
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分子式 C22H28O2S2 分子量388.59 Beilstein号 EC号 MFCD22420826 MDL号 MFCD22420826 PubChem编号 属性 溶解性 DMSO 78 mg/mL Water <1 mg/mL
| 货号 | CAS号 | 操作 |
|---|---|---|
| C127954-100mg | 95809-78-2 | 询底价 |
| C127954-10mg | 95809-78-2 | 询底价 |
| C127954-25mg | 95809-78-2 | 询底价 |
| C127954-5mg | 95809-78-2 | 询底价 |
耗材描述
- 分子式 C22H28O2S2
- 分子量388.59
- Beilstein号
- EC号 MFCD22420826
- MDL号 MFCD22420826
- PubChem编号
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | CPI-613是Lipoate类似物，能抑制丙酮酸脱氢酶（PDH）和α-酮戊二酸脱氢酶。 |
| 备注 | CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. Phase 2. |
| 生化机理 |
CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer. |
| 别名 | 6,8-双(苄硫基)辛酸;CPI 613;CPI613； 6,8-Bis[(phenylmethyl)thio-octanoic acid ；6,8-bis(benzylthio)octanoic acid； |
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