VU 0357121
面议
- 阿拉丁
- 生产商
- 国产
- 上海
- 现货
- 全国
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分子式 C17H17F2NO2 分子量305.32 Beilstein号 EC号 MFCD03243692 MDL号 MFCD03243692 PubChem编号 属性 溶解性 DMSO 61 mg/mL Water <1 mg/mL
| 货号 | CAS号 | 操作 |
|---|---|---|
| V129515-100mg | 433967-28-3 | 询底价 |
| V129515-10mg | 433967-28-3 | 询底价 |
| V129515-250mg | 433967-28-3 | 询底价 |
| V129515-50mg | 433967-28-3 | 询底价 |
耗材描述
- 分子式 C17H17F2NO2
- 分子量305.32
- Beilstein号
- EC号 MFCD03243692
- MDL号 MFCD03243692
- PubChem编号
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A novel allosteric modulator of mGluR-5 receptors |
| 产品介绍 | VU0357121是新型的mGlu5R正向变构调节剂，EC50为33 nM。 |
| 生化机理 | VU0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU0357121shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
| 别名 | 4-丁氧基-N-(2,4-二氟苯基)苯甲酰胺;VU0357121; VU-0357121; 4-Butoxy-N-(2,4-difluorophenyl)-benzamide |
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