Avagacestat (BMS-708163)-分析测试百科网

Avagacestat (BMS-708163)

面议

分子式 C20H17ClF4N4O4S 分子量520.89 EC号 MFCD13195458 属性溶解性 DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°

400-6699-117 转1000

耗材描述

溶解性	DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

备注	BMS-708163 is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
生化机理	BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM)
别名	(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide;(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide