B126453-1mgAvagacestat (BMS-708163)
面议
- 阿拉丁
- 生产商
- B126453-1mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C20H17ClF4N4O4S
- 分子量520.89
- EC号 MFCD13195458
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | BMS-708163 is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
生化机理 |
BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM) |
别名 | (2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide;(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide |
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