耗材描述

• 分子式 C₂₅H₂₇ClN₆O₃
• 分子量494.97

属性

溶解性	Soluble in DMSO (13 mg/ml) at 25 °C, water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C
存贮条件	储存温度-20°C

描述

应用	An EGFR phosphorylation inhibitor
产品介绍	WZ4002是一种新型的，突变选择性的EGFR抑制剂，作用于EGFR(L858R)/(T790M)时IC50为2 nM/8 nM；对ERBB2磷酸化(T798I)没有抑制作用。
备注	WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I).
生化机理	WZ 4002 is an inhibitor of EGFR phosphorylation in a variety of cancer cell lines including NIH-3T3 and H1975 cells. WZ 4002 is a potent inhibitor of EGFR, exhibiting an IC50 = 2 nM. This induces apoptosis in the cell due to the blocking of signal transduction from EGFR.
别名	WZ 4002; WZ-4002; N-[3-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氧基]苯基]-2-丙烯酰胺;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;WZ 4002; WZ-4002

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