Tyrphostin 9
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分子式 C18H22N2O 分子量282.38 Beilstein号 EC号 MFCD00209853 MDL号 MFCD00209853 PubChem编号 24278069 属性 沸点 ~386.8° C at 760 mmHg 熔点
| 货号 | CAS号 | 操作 |
|---|---|---|
| T129439-100mg | 10537-47-0 | 询底价 |
| T129439-25mg | 10537-47-0 | 询底价 |
| T129439-500mg | 10537-47-0 | 询底价 |
| T129439-50mg | 10537-47-0 | 询底价 |
耗材描述
- 分子式 C18H22N2O
- 分子量282.38
- Beilstein号
- EC号 MFCD00209853
- MDL号 MFCD00209853
- PubChem编号 24278069
属性
| 沸点 | ~386.8° C at 760 mmHg |
| 熔点 | 139-140° C |
| 折光率 | 1.56 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.1000 |
描述
| 应用 | Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells。 |
| 产品介绍 | Tyrphostin A9(AG 17)是51种酪氨酸激酶抑制剂，是线粒体分裂诱导剂。 |
| 生化机理 | Tyrphostin A9, a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings suggest that signaling via PDGF receptor tyrosine kinases is not necessary for the shift of the smooth muscle cells from a contractile to a synthetic phenotype. On the other hand these enzymes apparently carry out important functions in the control of intracellular membrane traffic and cell division. |
| 别名 | NSC 242557； RG-50872；AG 17; GCP 5126；3,5-二叔丁基-4-羟基亚苄基丙二腈;Tyrphostin A9; Tyrphostin AG 17；Malonaben； NSC 242557； RG-50872；3,5-di-tert-Butyl-4-hydroxybenzylidenemalonitrile; 2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol; |
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