耗材描述

• 分子式 C₂₂H₁₈N₄OS
• 分子量386.47
• Beilstein号
• EC号
• MDL号 MFCD09837898
• PubChem编号

属性

溶解性	Soluble in DMSO (42 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), methanol, and DMF (~0.25 mg/ml).,
存贮条件	储存温度-20°C

描述

应用	An inhibitor of Flt and Flk (VEGFR) with antitumor properties
产品介绍	Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β.
合法信息	Sold for research purposes under agreement from Pfizer Inc. - Not for human or veterinary use.
备注	Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
生化机理	Axitinib blocked phosphorylation of VEGFR-2 and VEGFR-3 with average IC50s of 0.2 and 0.1 to 0.3 nM.
别名	AG 013736;阿西替尼;AG-013736; N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide;

标识符号	GHS07, GHS09
信号词	Warning
危害声明	H302-H400
警示性声明	P273
WGK德国	3

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