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分子式 C30H28N6O6S4 分子量696.84 MDL号 MFCD00133163 PubChem编号 24893002 属性 存贮条件 储存温度2-8°C 密度 1.8700 //decorateTable('product-att
| 货号 | CAS号 | 操作 |
|---|---|---|
| C102377-1mg | 28097-03-2 | 询底价 |
耗材描述
- 分子式 C30H28N6O6S4
- 分子量696.84
- MDL号 MFCD00133163
- PubChem编号 24893002
属性
| 存贮条件 | 储存温度2-8°C |
| 密度 | 1.8700 |
描述
| 产品介绍 | Chaetocin, a natural product originally produced by Chaetomium species, is shown to have apoptotic effects on some cancer cells. Mechanistic studies show that chaetocin is taken up in the cells by a process that requires intact/unreduced disulfides for uptake. Once inside, this compound imposes oxidative stress and consequent apoptosis induction. Other studies have shown chaetocin to reduce lysine-specific histone methyltransferase effects of SUV39H, which play a key role in maintaining stable gene expression patterns during embryonic development and cellular differentiation. Additionally, this agent is reported to cause profound chromatin reorganization in fibroblast nuclei by inducing chromatin condensation/clustering. Consequentially, chaetocin impairs Trx (thioredoxin) systems, which are essential for deoxynucleotide synthesis and involved in a broad range of cellular functions. Chaetocin is an inhibitor of G9a, SUV39H1 and TrxR1. |
| 别名 | ; |
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