| 应用 |
An antiviral compound that can be used to induce apoptosis. |
| 产品介绍 |
Acyclovir 是一种合成的核苷类似物，有效作用于疱疹病毒。 |
| 备注 |
Acyclovir is a synthetic nucleoside analogue active against herpesviruses. |
| 生化机理 |
Acyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects through the alterations of the cell cycle in leukemia cells lines, such as p185BCR-ABL expressing OM9;22 cells, by synchronizing the G0/G1 phase. Formation of acycloguanosine triphosphate occurs through the phosphorylation of HSV-TK and can inhibit the viral DNA polymerase. Acyclovir also has the ability to inhibit the proliferation of the fibroblast cells, NIH 3T3, transformed with v-abl or bcr-abl. |
| 别名 |
阿昔洛韦;无环鸟苷;无环鸟嘌呤核苷;9-[(2-羟基乙氧基)甲基]鸟嘌呤;Acycloguanosine;9-[(2-Hydroxyethoxy)methyl]guanine;9-[(2-Hydroxyethoxy)methyl]guanine;2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one;2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one |
