| 应用 |
营养增补剂（铁质强化剂），是从猪血中提取的，现代医学公认的防治缺铁性贫血、吸收率高、效果好的往下生物铁源，无铁腥味，不刺激肠胃。是生产天然补铁食品、药品、保健品、化妆品的首选原料。
高铁血红素应用于以下应用中：
· 研究菌株和生长条件
· 用于短期菌落测定(培养基由血红素和其他成分组成)
· 细胞转染
它可用于分析MMV(抗疟药物)疟疾盒化合物对β-血红蛋白形成的抑制作用。 |
| 产品介绍 |
Hemin chloride, a heme oxygenase 1 inducer, is a porphyrin complex that is derived from erythrocytes. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-κB, hemin chloride has been shown to upregulate Egr-1 expression in vascular smooth muscle cells. It has also been used in solution to prepare agar medium for the cultivation of distinct bacteria. |
| 生化机理 |
高铁血红素是经氧化血红素，是一系列蛋白质的一种含铁的辅基基团。游离血红素在溶血后从血红蛋白中释放出来，具有促炎作用，有助于铁源活性氧的生成。游离血红素水平可在各种病理条件下上调，并可导致各种炎症条件，包括血管疾病、肾功能衰竭和免疫介导的疾病。高铁血红素可用于研究血红素加氧酶1 (HO-1)的表达和抑制以及HO-1的活性。 血凝素是生长流感嗜血杆菌所必需的“X因子”. |
| 别名 |
血晶素;卟啉铁;血晶质;亚铁原卟啉;氯高铁血红素;水溶性氯化血红素;氯(原卟啉酸)铁(III), 氯原卟啉IX铁(III), 高铁原卟啉IX氯, 高铁血红素（氯）;Teichmann's crystals; Ferriheme chloride; Chloroferriprotoporphyrin; Chloro(protoporphyrinato)iron(III);Chlorohemin Chloroprotoporphyrin IX iron(III);Ferriprotoporphyrin IX chloride;Hemin(chloride); |
