石杉碱甲
- 阿拉丁
- 生产商
- 国产
- 上海
- 现货
- 全国
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- 1
分子式 C15H18N2O 分子量242.32 Beilstein号 EC号 MDL号 MFCD01714949 PubChem编号 24895719 属性 溶解性 易溶于氯仿,溶于甲醇、乙醇,微溶于水 存贮条件 储存温度2-8℃ 密度 1
货号 | CAS号 | 价格 | 操作 |
---|---|---|---|
H107336-100mg | 102518-79-6 | 面议 | 询底价 |
H107336-25mg | 102518-79-6 | 面议 | 询底价 |
H107335-25mg | 102518-79-6 | ¥399.00 | 询底价 |
- 分子式 C15H18N2O
- 分子量242.32
- Beilstein号
- EC号
- MDL号 MFCD01714949
- PubChem编号 24895719
属性
溶解性 | 易溶于氯仿,溶于甲醇、乙醇,微溶于水 |
存贮条件 | 储存温度2-8℃ |
密度 | 1.2000 |
描述
应用 | 石杉碱甲不仅通过抑制胆碱酯酶活性,还可以通过影响自由基系统,降低生长抑素、细胞内[Ca2+]、谷氨酸含量,提高钙调蛋白(CaM)和钙调蛋白的信使核糖核酸(CaM mRNA)表达水平等多种药理机制,提高认知功能和学习记忆能力。 |
生化机理 |
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. |
别名 | (-)-石杉碱甲;(-)-Selagine |
Reaxys-RN | 3592896 |
标识符号 | GHS06 |
信号词 | Danger |
危害声明 | H300,H310,H315,H319,H330,H335 |
警示性声明 | P260,P264,P280,P284,P301+P310,P302+P350 |
个人防护设备 | Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges |
RTECS | PB9185700 |
WGK德国 | 3 |
风险声明 (欧洲) | R26/27/28;R36/37/38; |
安全声明(欧洲) | S26;S36/37/39/;S45; |
危害码(欧洲) | T+ |
UN代码 | 1544 |