N,N,N',N'-四(2-吡啶甲基)乙二胺-分析测试百科网

N,N,N',N'-四(2-吡啶甲基)乙二胺

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
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分子式 C26H28N6 分子量424.55 Beilstein号 EC号 MDL号 MFCD00036918 PubChem编号属性 //decorateTable('product-attribute-specs-table') 描述

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
N159625-1G	16858-02-9	询底价
N159625-250mg	16858-02-9	询底价
N159625-5G	16858-02-9	询底价

耗材描述

分子式 C₂₆H₂₈N₆
分子量424.55
Beilstein号
EC号
MDL号 MFCD00036918
PubChem编号

属性

描述

应用	N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine has been used: · in the treatment of human embryonic kidney (HEK293T) cells for assessing its effect on the Jembrana disease virus (JDV) viral infectivity factor (Vif) functionality · in P19 embryonic carcinoma cells for chelation of zinc ions released during apoptosis · to evaluate its effect on lentiviral Vpx infection on human monocytic THP-1 cells
生化机理	N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling.[1] In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression.[2] It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells. TPEN是一种可透过膜的锌螯合剂；可降低细胞内锌水平并诱导细胞凋亡（即细胞收缩和凋亡小体的形成、DNA片段化和形成典型的DNA梯状带）。
别名	;TPEN;TPEDA

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