C111282-100mg(S)-(+)-喜树碱
面议
- 阿拉丁
- 生产商
- C111282-100mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C20H16N2O4
- 分子量348.35
- Beilstein号 631069
- EC号
- MDL号 MFCD00081076
- PubChem编号 24278352
属性
熔点 | 259-263°C |
溶解性 | Soluble in chloroform/methanol (4:1) (4 mg/ml), DMSO (10 mg/ml), methanol (40 mg/ml), 0.1N sodium hydroxide (50 mg/ml), and acetic acid. Insoluble in water. |
存贮条件 | 储存温度2-8℃ |
密度 | 1.5100 |
描述
应用 | 不可逆转地的结合到DNA拓扑异构酶I复合物上,影响细胞周期进程 |
产品介绍 | 微溶于乙醇、氯仿,难溶于水。与酸不能生成稳定的盐,与氢氧化钠溶液加热反应可生成钠盐而溶于水。钠盐水溶液黄色澄明具蓝色荧光 |
生化机理 | (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes. |
别名 | 喜树碱;4-乙基-4-羟基-1H-吡喃[3',4':6,7]氮茚[1,2]喹啉-3,14(4H,12H)-二酮4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
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