(S)-(+)-喜树碱
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分子式 C20H16N2O4 分子量348.35 Beilstein号 631069 EC号 MDL号 MFCD00081076 PubChem编号 24278352 属性 熔点 259-263°C 溶解性 Soluble in chlor
| 货号 | CAS号 | 操作 |
|---|---|---|
| C111282-100mg | 7689-03-4 | 询底价 |
| C111282-5g | 7689-03-4 | 询底价 |
| C111282-1g | 7689-03-4 | 询底价 |
| C111282-250mg | 7689-03-4 | 询底价 |
耗材描述
- 分子式 C20H16N2O4
- 分子量348.35
- Beilstein号 631069
- EC号
- MDL号 MFCD00081076
- PubChem编号 24278352
属性
| 熔点 | 259-263°C |
| 溶解性 | Soluble in chloroform/methanol (4:1) (4 mg/ml), DMSO (10 mg/ml), methanol (40 mg/ml), 0.1N sodium hydroxide (50 mg/ml), and acetic acid. Insoluble in water. |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.5100 |
描述
| 应用 | 不可逆转地的结合到DNA拓扑异构酶I复合物上，影响细胞周期进程 |
| 产品介绍 | 微溶于乙醇、氯仿，难溶于水。与酸不能生成稳定的盐，与氢氧化钠溶液加热反应可生成钠盐而溶于水。钠盐水溶液黄色澄明具蓝色荧光 |
| 生化机理 | (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes. |
| 别名 | 喜树碱;4-乙基-4-羟基-1H-吡喃[3'，4'：6，7]氮茚[1，2]喹啉-3，14(4H，12H)-二酮4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
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