Gö6976,>99%,其它生化试剂

Biological Activity:

Potent protein kinase C (PKC) inhibitor (IC₅₀ = 7.9 nM). Discriminates between Ca²⁺-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKC-alpha and PKC beta-1 (IC₅₀ values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKC delta, -epsilon, or - zeta (IC₅₀ > 3uM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC₅₀ values are 5, 30, 130 and 370 nM respectively), PKC-mu (PKD1) and the mitotic spindle checkpoint.

Synonym

PD 406976

Go 6976

Store at -20^oC, Desiccate

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