Vatalanib,DihydrochlorideSalt,>99%,其它生化试剂

Vatalanib inhibits the VEGF-induced phosphorylation with an IC₅₀ of 17 nM and 34 nM for the HUVECs and CHO cells, respectively. Furthermore, Vatalanib shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs with and IC₅₀ of 7.1 nM, and dose-dependently suppresses VEGF-induced survival and migration of endothelial cells in the same dose range without cytotoxic or antiproliferative effect on cells that do not express VEGF receptors. [1] A recent study shows that Vatalanib significantly inhibits the growth of hepatocellular carcinoma cells and enhances the IFN/5-FU induced apoptosis by increasing proteins levels of Bax and reduced Bcl-xL and Bcl-2.

Cat No	Size	Price($)

BC099-025	25mg	98

BC099-100	100mg	193

M.W 419.73

Formular C₂₀H₁₅ClN₄.2HCl

Solubility Soluble in DMSO at 10-20 mg/mL

Purity >99%

Biological Activity

Vatalanib inhibited VEGF-induced phosphorylation (IC₅₀'s of 17 nM and 34 nM for HUVECs and CHO cells, respectively), blocked thymidine incorporation induced by VEGF in HUVECs (IC₅₀ = 7.1 nM), prevented VEGF-induced HUVEC migration dose dependently (IC₅₀ = 58 nM), and inhibited tumor cell proliferation with an IC₅₀ of 17 uM and 18 uM for A431 and DU145 cells, respectively and sprout formation in rat aortas (IC₅₀ = 675 nM).

Synonym

CGP-79787,PTK 787, ZK222584

Store at -20^oC, Desiccate

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