ACVR1C Antibody(Center E271)
Cat.#: T2019
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q8NER5
Mol Weight: 55kDa
Size: 100ug

Description
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

Recommended Applications
WB, ELISA

Applications and Recommended Dilution Factors
WB: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data

 
Western blot analysis of anti-ACVR1C Antibody (Center) in Hela cell line lysates (35ug/lane). ACVR1C (arrow) was detected using the purified Pab.

Specificity
This ACVR1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263~292 amino acids from the center region of human ACVR1C.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ACVR1C antibody, ACVRLK7 antibody, ALK7 antibody, Activin receptor type-1C antibody, Activin receptor-like kinase 7 antibody

Description References
Munir, S., et al., J. Biol. Chem. 279(30):31277-31286 (2004).
Kim, B.C., et al., J. Biol. Chem. 279(27):28458-28465 (2004).
Roberts, H.J., et al., Biol. Reprod. 68(5):1719-1726 (2003).
Tsuchida, K., et al., Mol. Cell. Endocrinol. 220 (1-2), 59-65 (2004).
Bondestam, J., et al., Cytogenet. Cell Genet. 95 (3-4), 157-162 (2001). 

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途