AK3(AKL3L)Antibody(C-term)
Cat.#: T3053
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q9UIJ7
Mol Weight: 25kDa
Size: 100ug

Description
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Recommended Applications
WB, IHC, ELISA

Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data 

 

Western blot analysis of AKL3L (arrow) using rabbit polyclonal hAKL3L-Q213 . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the AKL3L gene (Lane 2).
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Specificity
This AK3 (AKL3L) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198~227 amino acids from the C-terminal region of human AKL3L.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Alternative Names
AK3 antibody, AK3L1 antibody, AK6 antibody, AKL3L antibody, AKL3L1 antibody, FIX antibody, GTP:AMP phosphotransferase, mitochondrial antibody, Adenylate kinase 3 alpha-like 1 antibody

Description References
Noma, T., et al., Biochem. Biophys. Res. Commun. 264(3):990-997 (1999).
Noma, T., et al., Biochem. J. 358 (Pt 1), 225-232 (2001). 

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途