Angiotensinogen(AGT)antibody
Cat.#: 3249-1
Rabbit Monoclonal Antibody
Clone ID: EPR2930(2)
Swiss Prot: P01019
Mol Weight: 52/ 64kDa
Size: 100ul

Description
Angiotensinogen is a precursor of angiotensin-1, 2, and 3; as a member of the serpin family, it is expressed by the liver and secreted in plasma. In response to lowered blood pressure, renin cleaves Angiotensinogen and produces angiotensin-1 (1). Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while Angiotensin-3 stimulates aldosterone release (2). Defects in Angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension (3).

Recommended Applications
WB, ICC, IP, FC

Applications and Recommended Dilution Factors
WB: 1:10,000 - 50,000
ICC: 1:500 - 1000
IP: 1:10 - 100
FC: 1:100 - 500

Species Reactivity
Human

Species cross-reactivity is based on WB analysis

Products Data

Western blot analysis on (A) fetal kidney, (B) fetal artery, (C) fetal heart, (D) HepG2, and (E) human plasma lysates using anti-Angiotensinogen RabMAb (cat. #3249-1).

Specificity
A synthetic peptide corresponding to residues in human Angiotensinogen was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
AGT antibody, ANHU antibody, FLJ92595 antibody, FLJ97926 antibody, SERPINA8 antibody, Angiotensin-3 antibody, Des-Asp[1]-angiotensin II antibody

Description References
1. Tainmoto K et al. JBC, 269(50):31334-7, 1994.
2. Kilian P et al. Endocrinology 149 (6):2923-2933, 2008.
3. The UniProt Consortium, The Universal Protein Resource (UniProt) Nucleic Acids Res. 36:D190-D195(2010).

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途