AFP(C-term)antibody
Cat.#: 1791-1
Rabbit Monoclonal Antibody
Clone ID: EP1017Y
Swiss Prot: P02771
Mol Weight: 70kDa
Size: 100ul

Description
Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways (2). AFP functions as a binding and transporting ligand and cell growth regulator. Elevated expression level of AFP has been implicated in colorectal, ovarian, pancreatic, testicular, and certain liver cancers. High levels of AFP is also seen in some diseases such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drugs-ligand carrier, transporting drugs to target tumor cells, increasing anti-tumor efficiency (3).

Recommended Applications
WB, IHC, IP

Applications and Recommended Dilution Factors
WB: 1:1,000 - 2,000
IHC: 1:250-500
IP: 1:50

Species Reactivity
Human

Cross reactivity determined by western blot only.

Products Data 

 

A. Western blot analysis on HepG2 membrane using anti-AFP RabMAb (cat. # 1791-1), dilution 1:50.000
B. Immunohistochemical staining of paraffin-embedded human fetal liver using anti-AFP RabMAb (cat. # 1791-1).

Specificity
A synthetic peptide corresponding to residues near the C-term of human AFP was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
AFP antibody, FETA antibody, HPAFP antibody, Alpha-fetoprotein antibody, Alpha-1-fetoprotein antibody, Alpha-fetoglobulin antibody

Description References
1. Wang XW, et al. World J Gastroenterol 7:345-351, 2001.
2. Chen H, et al Crit Rev Eukaryot Gene Expr, 7:11-41, 1997.
3. Zheng AI, et al. CJC 22:108-111, 2003.

AFP(C-term)antibody信息由上海高创化学科技有限公司为您提供，如您想了解更多关于AFP(C-term)antibody报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途