8-oxoguanine DNA-glycosylase 1 isoform 2a antibody
Cat.#: S0675
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: O15527
Mol Weight: 47.25kDa
Size: 100ug

Description
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq]

Recommended Applications
WB

Applications and Recommended Dilution Factors
WB: 1:500-1:3000

Species Reactivity
Human

Other species have not been tested

Products Data

Sample (30ug of whole cell lysate)
A: Molt-4
10% SDS PAGE
diluted at 1:1000

Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 322 of Human OGG1

Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.

Alternative Names
OGG1 antibody, HMMH antibody, HOGG1 antibody, MUTM antibody, OGH1 antibody, DNA-(apurinic or apyrimidinic site) lyase antibody, antibody

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