Abi-2(ABI2)antibody
Cat.#: 3189-1
Rabbit Monoclonal Antibody
Clone ID: EPR3906
Swiss Prot: Q9NYB9
Mol Weight: 75kDa
Size: 100ul

Description
Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for Rac-dependent cytoskeletal reorganization in response to growth factor stimulation (1). Abi-2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases Abi-1 and/or Abi-2. This protein may be involved in cytoskeletal reorganization, and it regulates Abi-1/c-Abl-mediated phosphorylation of MENA (2).

Recommended Applications
WB, IHC, ICC, IP

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
ICC: 1:500 - 1,000
IP: 1:10 - 100

Species Reactivity
Human, Mouse, Rat

Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only

Products Data

 

 
Western blot analysis on (A) HeLa, (B) Jurkat, (C) K562, (D) SH-SY5Y, and (E) HepG2 cell lysates using anti-Abi-2 RabMAb (cat. #3189-1).
Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Abi-2 RabMAb (cat. #3189-1).
Immunofluorescent staining of HeLa cells using anti-Abi-2 RabMAb (cat. #3189-1).

Specificity
A synthetic peptide corresponding to residues in human Abi-2 was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ABI2 antibody, ABI-2 antibody, ABI2B antibody, AIP-1 antibody, AblBP3 antibody, SSH3BP2 antibody, argBPIA antibody, argBPIB antibody, Abl interactor 2 antibody, Arg-binding protein 1 antibody

Description References
1. Courtney KD, et al. Mol Cell Neurosci 16(3):244-57, 2000
2. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2010)

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