AKT2 Antibody(Center)
Cat.#: T1931
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P31751
Mol Weight: 56kDa
Size: 100ug

Description
AKT2 is a putative oncogenic protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.

Recommended Applications
WB, ELISA

Applications and Recommended Dilution Factors
WB: 1:100~500
ELISA: 1:1,000

Species Reactivity
Human

Products Data

 
Western blot analysis of AKT2 (arrow) using rabbit polyclonal AKT2 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the AKT2 gene (Lane 2) (Origene Technologies).

Specificity
This AKT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101~131 amino acids from the center region of human AKT2.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Alternative Names
AKT2 antibody, PKBB antibody, PKBBETA antibody, PRKBB antibody, RAC-BETA antibody, RAC-beta serine/threonine-protein kinase antibody, RAC-PK-beta antibody

Description References
Vojtek, A.B., et al., Mol. Cell. Biol. 23(13):4417-4427 (2003).
Yuan, Z.Q., et al., J. Biol. Chem. 278(26):23432-23440 (2003).
Jones, D.T., et al., Blood 101(8):3174-3180 (2003).
Brozinick, J.T. Jr., et al., Diabetes 52(4):935-941 (2003).
Miyakawa, M., et al., Endocr. J. 50(1):77-83 (2003).

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途