Aromatase(CYP19A1)antibody
Cat.#: 5233-1
Rabbit Monoclonal Antibody
Clone ID: EPR4534(2)
Swiss Prot: P11511
Mol Weight: 53kDa
Size: 100ul

Description
Aromatase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Aromatase localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in Aromatase can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation (1).

Recommended Applications
WB, IP, FC

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IP: 1:10 - 100
FC: 1:100 - 500

Species Reactivity
Human, Rat

Species cross-reactivity is based on WB analysis.

Products Data 

 

Western blot analysis on (A) human placenta, (B) human uterus, (C) JAR, and (D) NIH:OVCAR-3 lysates using anti-Aromatase RabMAb (cat. #5233-1).
Flow cytometric analysis of permeabilized NIH:OVCAR-3 cells using anti-Aromatase RabMAb (red) (catalog # 5233-1) or a rabbit IgG (negative) (green). 

Specificity
A synthetic peptide corresponding to residues in human Aromatase was used as an immunogen.

Storage Condition and Buffer
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
CYP19A1 antibody, ARO antibody, ARO1 antibody, CPV1 antibody, CYAR antibody, CYP19 antibody, MGC104309 antibody, P-450AROM antibody, Cytochrome P450 19A1 antibody, Aromatase antibody, CYPXIX antibody, Cytochrome P-450AROM antibody, Estrogen synthase antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.

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