Atg7(ATG7)antibody
Cat.#: 2054-1
Rabbit Monoclonal Antibody
Clone ID: EP1759Y
Swiss Prot: O95352
Mol Weight: 72kDa
Size: 100ul

Description
Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome/vacuole and has a significant relationship to several neurodegenerative disorders and myopathies in mammals (1). Apg7 (Atg7) is a unique E1 enzyme which is essential for both the Apg12p- and Apg8p-modification systems, and plays indispensable roles in autophagy (2). A new molecular pathway has been defined in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required Atg7 and beclin 1 and was induced by caspase-8 inhibition (3).

Recommended Applications
WB, IHC, ICC, IP, FC

Applications and Recommended Dilution Factors
WB: 1:100,000 - 200,000
IHC: 1:100 - 250
ICC: 1:250 - 500
IP: 1:50
FC: 1:95

Species Reactivity
Human

Cross reactivity determined by western blot only.

Products Data 

 

A. Western blot analysis on Jurkat cell lysate using anti-Atg7 RabMAb (cat. # 2054-1).
B. Immunohistochemical analysis of paraffin-embedded human liver using anti-Atg7 RabMAb (cat. #2054-1).

Specificity
A synthetic peptide corresponding to residues near the C-terminus of human Atg7 was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ATG7 antibody, APG7-LIKE antibody, APG7L antibody, DKFZp434N0735 antibody, GSA7 antibody, Ubiquitin-like modifier-activating enzyme ATG7 antibody, Ubiquitin-activating enzyme E1-like protein antibody

Description References
1. Tanida I, et al. J. Biol Chem 277(16):13739-44, 2002
2. Tanida I, et al. Biochem Biophys Res 292(1):256-62, 2002
3. Yu L, et al. Science 304(5676):1500-2, 2004

Product References
1. Yang S, Wang X, Contino G, et al, Pancreatic cancers require autophagy for tumor growth ,Genes Dev 25 (2011) 717-729 

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