ATGL(PNPLA2)antibody
Cat.#: 3370-1
Rabbit Monoclonal Antibody
Clone ID: EPR3444(2)
Swiss Prot: Q96AD5
Mol Weight: 54kDa
Size: 100ul

Description
Adipose triglyceride lipase (ATGL) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. It also has acylglycerol transacylase activity. ATGL may act coordinately with LIPE/HLS within the lipolytic cascade. It regulates adiposome size and may be involved in the degradation of adiposomes (1). Activity of ATGL is regulated by an activator protein annotated as α/β-fold domain-containing protein 5 (ABHD5), also known as CGI-58 (comparative gene identification 58) (2). Its highest expression is in adipose tissue (1).

Recommended Applications
WB, ICC

Applications and Recommended Dilution Factors
WB: 1:1,000-10,000
ICC: 1:100 - 250

Species Reactivity
Human, Mouse, Rat

Species cross-reactivity is based on WB analysis

Products Data

 
Western blot analysis on (A) 3T3-L1, (B) A431, (C) A673, (D) human heart, (E) human skeletal muscle, and (F) human adipose tissue lysates using anti-ATGL RabMAb (cat. #3370-1).

Specificity
A synthetic peptide corresponding to residues in human ATGL was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
PNPLA2 antibody, 1110001C14Rik antibody, ATGL antibody, DKFZp667M109 antibody, PEDF-R antibody, TTS-2.2 antibody, TTS2 antibody, Patatin-like phospholipase domain-containing protein 2 antibody, Adipose triglyceride lipase antibody, Calcium-independent phospholipase A2 antibody, Desnutrin antibody, IPLA2-zeta antibody, Pigment epithelium-derived factor antibody, TTS2.2 antibody, Transport-secretion protein 2 antibody

Description References
1. The UniProt Consortium. The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010).
2. Chandak PG et al. Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J Biol Chem. 2010 Jun 25;285(26):20192-201.

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途