Myriocin;CAS:35891-70-4正品订购,其它生化试剂

BML-SL226-0005 5 mg
Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. BML-A195). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (Ki=0.28nM), therefore useful as a tool to deplete cells of sphingolipids. Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC50=15nM).
Product Specification
Alternative Name: ISP-1, Thermozymocidin, 2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid
Formula: C21H39NO6
MW: 401.5
Purity: ≥98% (TLC)
Appearance: White to off-white solid.
CAS: 35891-70-4
RTECS: JX3890000
Solubility: Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Hazard: HARMFUL.
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