Wortmannin；CAS:19545-26-7原装订购,其它生化试剂

BML-ST415-0020 20 mg
BML-ST415-0005 5 mg
BML-ST415-0001 1 mg
Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Inhibits fMLP induced PIP3 and superoxide anion production (IC50 = 50nM) in guinea pig neutrophils and blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase.
The half-life of wortmannin in culture media is quite short (8-13 minutes), care should be taken to account for this decomposition when planning experiments. Markedly potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau.
Product Specification
Alternative Name: KY 12420
Formula: C23H24O8
MW: 428.4
Purity: ≥98% (TLC)
Appearance: White to off-white solid.
CAS: 19545-26-7
MI: 14: 10053
RTECS: CB9641000
Solubility: Soluble in DMSO (50mg/ml), methanol (5mg/ml) or 100% ethanol (25mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Make solutions fresh immediately before use. DO NOT STORE SOLUTIONS.
Hazard: VERY TOXIC.
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