AP-18;CAS:55224-94-7装正品,其它生化试剂

BML-CA239-0025 25 mg
BML-CA239-0005 5 mg
AP-18 is a novel TRPA1 channel blocker (CHO cells, IC50= 3.1µM; human and mouse cell lines, IC50= 4.5µM). It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs TRPV1. AP-18 was unable to block activation of TRPV1, TRPV2, TRPV3, TRPV4 or TRPM8 at concentrations up to 50μM. It reverses CFA-induced mechanical hyperalgesia in mice.
Product Specification
MW: 209.7
Purity: 98%
CAS: 55224-94-7
Shipping: AMBIENT
Long Term Storage: Ambient
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